[Facial Skin Aging: an overview of biological aging processes]

Facial Skin Aging: an overview of biological aging processes

David Zargaran1,  Florence Zoller1,  Alexander Zargaran2,  Tim Weyrich3,4,  Afshin Mosahebi1

1 Royal Free Hospital, University College London
2 St Thomas’s Hospital, London
3 University College London
4 Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)

Abstract

Introduction: The face is a cosmetically sensitive region where the process of aging is most clearly manifested. With increased focus on anti-aging and longevity, more anti-senescent treatments are being proposed despite limited evidence. This study outlines the pathways and mechanisms underpinning the biological process of aging in the face. Methods: Comprehensive searches of MEDLINE, EMBASE, Cochrane Library and CINAHL from inception to 2020. Inclusion criteria included all empirical human research studies specific to facial aging features, written in the English language. Results: A total of 65 papers met inclusion criteria for analysis. Pathways were subdivided into intrinsic and extrinsic senescence mechanisms. Intrinsic pathways included genetics, generation of reactive oxygen species and hormonal changes. Extrinsic pathways included photoageing and damage to skin layers. The combined intrinsic and extrinsic pathway alterations result in wrinkles, higher laxity, slackness and thinning of the skin. Skin functions such as barrier immune function, wound healing, thermoregulation and sensory function are also impaired. Conclusion: The aging process is unique to the individual and depends on the interplay between an individual’s genetics and external environmental factors. Through understanding the molecular and cellular mechanisms, an appreciation of the consequent structural and functional changes can be achieved. Based on this knowledge further research can focus on how to slow or impede the aging process and identify specific targets to develop and evolve new treatment strategies.

Citation Style:    Publication

Facial Skin Aging: an overview of biological aging processes.
David Zargaran, Florence Zoller, Alexander Zargaran, Tim Weyrich, Afshin Mosahebi.
International Journal of Cosmetic Science, 44, pp. 414–420, Wiley, April 2022.
David Zargaran, Florence Zoller, Alexander Zargaran, Tim Weyrich, and Afshin Mosahebi. Facial skin aging: an overview of biological aging processes.International Journal of Cosmetic Science, 44:414–420, April 2022.Zargaran, D., Zoller, F., Zargaran, A., Weyrich, T., and Mosahebi, A. 2022. Facial skin aging: an overview of biological aging processes. International Journal of Cosmetic Science 44 (Apr.), 414–420.D. Zargaran, F. Zoller, A. Zargaran, T. Weyrich, and A. Mosahebi, “Facial skin aging: an overview of biological aging processes,” International Journal of Cosmetic Science, vol. 44, pp. 414–420, Apr. 2022. [Online]. Available: https://doi.org/10.1111/ics.12779

Privacy: This page is free of cookies or any means of data collection. Copyright disclaimer: The documents contained in these pages are included to ensure timely dissemination of scholarly and technical work on a non-commercial basis. Copyright and all rights therein are maintained by the authors or by other copyright holders, notwithstanding that they have offered their works here electronically. It is understood that all persons copying this information will adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.